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Phospho-STK11 (Thr189) Recombinant Rabbit Monoclonal Antibody (5J9), CoraLite® 594
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FIGURE: 1 / 1
Phospho-STK11 (Thr189) Antibody (CL594-80127) in Flow
1X10^6 PC-3 cells untreated (dashed lines) or treated with Calyculin A (red) were intracellularly stained with 0.13 µg CoraLite®594 Anti-Human Phospho-STK11 (Thr189) (CL594-80127, Clone:5J9), or 0.13 µg Control Antibody (blue). Cells were fixed with 4% PFA and permeabilized with 90% MeOH.
Product Details
CL594-80127
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Mammalian cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5J9
Immunogen
Peptide
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAMK group; CAMKL family; Liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; STK11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11; unnamed protein product
Gene Aliases: AA408040; hLKB1; LKB1; Par-4; PJS; R75140; STK11
UniProt ID: (Human) Q15831, (Mouse) Q9WTK7
Entrez Gene ID: (Human) 6794, (Mouse) 20869
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
protein dephosphorylation
autophagy
apoptotic process
cellular response to DNA damage stimulus
signal transduction
spermatogenesis
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
peptidyl-threonine phosphorylation
establishment of cell polarity
regulation of Wnt signaling pathway
cell differentiation
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
protein localization to nucleus
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of axonogenesis
T cell receptor signaling pathway
Golgi localization
regulation of cell cycle
regulation of protein kinase B signaling
epithelial cell proliferation involved in prostate gland development
negative regulation of epithelial cell proliferation involved in prostate gland development
G1 to G0 transition
cellular response to UV-B
intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of canonical Wnt signaling pathway
dendrite extension
negative regulation of cold-induced thermogenesis
positive regulation of protein localization to nucleus
positive regulation of vesicle transport along microtubule
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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