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Proteintech

GSTP1 Monoclonal Antibody (2D4A6), CoraLite® 594

View all (32) GSTP1 antibodies

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Product Details

CL59466715100UL

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2D4A6

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Chain 7; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III; Glutathione S-transferase P; glutathione S-transferase pi 2; glutathione S-transferase, pi 2; Glutathione-S-transferase placental enzyme pi type; glutathione-S-transferase, pi 1; Glutathione-S-transferase, placental enzyme pi type; GST 7-7; GST class-pi; GSTP1; GSTP1-1; HGNC:4638; unnamed protein product

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Gene Aliases: DFN7; FAEES3; GST-P; GST3; GSTP; GSTP1; Gstp2; HEL-S-22; PI

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UniProt ID: (Human) P09211, (Rat) P04906

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Entrez Gene ID: (Human) 2950, (Rat) 24426

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Function(s)
glutathione transferase activity glutathione peroxidase activity fatty acid binding protein binding JUN kinase binding toxic substance binding transferase activity protein kinase binding protein serine/threonine kinase inhibitor activity S-nitrosoglutathione binding dinitrosyl-iron complex binding nitric oxide binding drug binding kinase regulator activity glutathione binding transferase
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to reactive oxygen species negative regulation of acute inflammatory response lipid metabolic process prostaglandin metabolic process glutathione metabolic process xenobiotic metabolic process central nervous system development response to toxic substance negative regulation of tumor necrosis factor-mediated signaling pathway oligodendrocyte development organ regeneration response to nutrient levels response to estradiol negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production cellular response to insulin stimulus regulation of stress-activated MAPK cascade negative regulation of stress-activated MAPK cascade positive regulation of superoxide anion generation response to L-ascorbic acid common myeloid progenitor cell proliferation nitric oxide storage negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid negative regulation of MAPK cascade linoleic acid metabolic process response to ethanol negative regulation of JNK cascade negative regulation of fibroblast proliferation hepoxilin biosynthetic process regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade negative regulation of leukocyte proliferation cellular response to lipopolysaccharide cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to cell-matrix adhesion negative regulation of monocyte chemotactic protein-1 production negative regulation of smooth muscle cell chemotaxis cellular oxidant detoxification glutathione derivative biosynthetic process negative regulation of vascular smooth muscle cell proliferation negative regulation of extrinsic apoptotic signaling pathway negative regulation of protein kinase activity negative regulation of biosynthetic process negative regulation of MAP kinase activity negative regulation of JUN kinase activity response to mercury ion negative regulation of nitric-oxide synthase biosynthetic process negative regulation of peroxidase activity
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