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Bethyl Laboratories
CLASP2 Polyclonal Antibody
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FIGURE: 1 / 1
CLASP2 Antibody (A302-154A) in IP
Detection of human CLASP2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-CLASP2 antibody (Product # A302-154A) used for IP at 3 µg/mg lysate. CLASP2 was also immunoprecipitated by rabbit anti-CLASP2 antibody A302-155A, which recognizes a downstream epitope. For blotting immunoprecipitated CLASP2, A302-155A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time 30 seconds.
Product Details
A302-154A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 and 50 of human cytoplasmic linker associated protein 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CLIP-associating protein 2; CLIP-associating protein CLASP2; Cytoplasmic linker-associated protein 2; hOrbit2; multiple asters (Mast)-like homolog 2; Protein Orbit homolog 2
Gene Aliases: CLASP2; KIAA0627
UniProt ID: (Human) O75122
Entrez Gene ID: (Human) 23122
microtubule cytoskeleton organization
vesicle targeting
microtubule nucleation
negative regulation of microtubule depolymerization
Golgi organization
mitotic spindle organization
sister chromatid cohesion
establishment or maintenance of cell polarity
exit from mitosis
regulation of gastrulation
positive regulation of epithelial cell migration
regulation of epithelial to mesenchymal transition
microtubule organizing center organization
regulation of microtubule polymerization or depolymerization
regulation of microtubule-based process
microtubule anchoring
positive regulation of exocytosis
cell division
negative regulation of stress fiber assembly
negative regulation of focal adhesion assembly
establishment of protein localization to plasma membrane
positive regulation of extracellular matrix disassembly
negative regulation of wound healing, spreading of epidermal cells
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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