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Product Details
MA5-31404
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1 µg/mL | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
CL4844 |
Immunogen |
Recombinant protein corresponding to Human CLIP1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2787040 |
Product Specific Information
Immunogen sequence: KNLELQLKEN KRQLSSSSGN TDTQADEDER AQESQIDFLN SVIVDLQRKN QDLKMKVEMM SEAALNGNGD DLNNYDSDDQ EKQSKKKPRL FCDICDCFDL HDTEDCPTQA QMSEDPPHST HHGSRGEERP YCEICEMFGH WATNCNDDET
Target Information
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP-Gly domain-containing linker protein 1; CLIP-170; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein CLIP-170; MGC131604; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
Gene Aliases: CLIP; CLIP-170; CLIP1; CLIP170; CYLN1; RSN
UniProt ID: (Human) P30622
Entrez Gene ID: (Human) 6249
Molecular Function:
chaperone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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