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Invitrogen
CLSTN2 Polyclonal Antibody
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Product Details
PA5-47745
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Calsyntenin-2 Ser21-Thr834 (Val366Ile)
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Calsyntenin-1 and rhCalsyntenin-3 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Calsyntenin 2 (CLSTN2) is a gene located on chromosome 3p22.2 that encodes a member of the calsyntenin family of proteins, which are characterized by their role in calcium binding and involvement in synaptic function and neural connectivity. CLSTN2 is predominantly expressed in the nervous system, where it contributes to synaptic organization and signaling processes essential for neural plasticity and cognitive functions. The protein is involved in mediating vesicular transport and axonal trafficking, influencing the establishment and maintenance of synaptic connections. Altered expression or mutations in CLSTN2 have been linked to neurological disorders, including Alzheimer's disease, suggesting its significance in maintaining neural circuit stability and memory processes. Current research continues to explore CLSTN2's functional roles in neurobiology, with potential therapeutic implications for enhancing synaptic function and addressing neurodegenerative conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alc-gamma; alcadein gamma; Alcadein-gamma; cadherin-related family member 13; Calsyntenin-2; CS2alcadein-gamma; FLJ39113; FLJ39499; MGC119560; unnamed protein product
Gene Aliases: ALC-GAMMA; alcagamma; CDHR13; CLSTN2; CS2; CSTN2
UniProt ID: (Human) Q9H4D0
Entrez Gene ID: (Human) 64084
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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