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Invitrogen
CMG1 Polyclonal Antibody
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FIGURE: 1 / 1
CMG1 Antibody (PA5-109848) in WB
Western blot analysis of CMG1 in extracts of various cell lines. Samples were incubated with CMG1 Polyclonal antibody (Product # PA5-109848) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-109848
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-372 of human IFT74 (NP_001092694.1).
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Amount
32 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MASNHKSSAA RPVSRGGVGL TGRPPSGIRP LSGNIRVATA MPPGTARPGS RGCPIGTGGV LSSQIKVAHR PVTQQGLTGM KTGTKGPQRQ ILDKSYYLGL LRSKISELTT EVNKLQKGIE MYNQENSVYL SYEKRAETLA VEIKELQGQL ADYNMLVDKL NTNTEMEEVM NDYNMLKAQN DRETQSLDVI FTERQAKEKQ IRSVEEEIEQ EKQATDDIIK NMSFENQVKY LEMKTTNEKL LQELDTLQQQ LDSQNMKKES LEAEIAHSQV KQEAVLLHEK LYELESHRDQ MIAEDKSIGS PMEEREKLLK QIKDDNQEIA SMERQLTDTK EKINQFIEEI RQLDMDLEEH QDPTNYGWKI LEKNTGSFKK QV
Target Information
This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Capillary morphogenesis gene 1 protein; capillary morphogenesis protein 1; CMG-1; CMG-1; with coiled-coil domains; coiled-coil domain containing 2; Coiled-coil domain-containing protein 2; intraflagellar transport 74 homolog; Intraflagellar transport protein 74 homolog; unnamed protein product
Gene Aliases: 1700029H06Rik; b2b796Clo; BBS22; CCDC2; CMG-1; CMG1; IFT74; JBTS40; SPGF58
UniProt ID: (Human) Q96LB3, (Mouse) Q8BKE9
Entrez Gene ID: (Human) 80173, (Mouse) 67694, (Rat) 313365
keratinocyte development
Notch signaling pathway
epidermis development
cell projection organization
positive regulation of cell adhesion mediated by integrin
intraciliary transport involved in cilium morphogenesis
intraciliary transport
cilium assembly
positive regulation of transcription from RNA polymerase II promoter
negative regulation of epithelial cell proliferation
cilium morphogenesis
determination of left/right symmetry
heart development
negative regulation of keratinocyte proliferation
intraciliary anterograde transport
keratinocyte proliferation
non-motile cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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