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CMPK2 Polyclonal Antibody
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Product Details
600-401-AM1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-CMPK2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the C-terminus of human CMPK2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; cytidylate kinase 2; mitochondrial UMP-CMP kinase; Nucleoside-diphosphate kinase; thymidine monophosphate kinase 2; thymidylate kinase family LPS-inducible member; thymidylate kinase homologue; Thymidylate kinase LPS-inducible member; TYKi; UMP-CMP kinase 2, mitochondrial; UMP/CMP kinase; unnamed protein product
Gene Aliases: 1200004E04Rik; CMPK2; IBGC10; NDK; TDKI; TMPK2; TYKi; UMP-CMPK2
UniProt ID: (Human) Q5EBM0, (Mouse) Q3U5Q7
Entrez Gene ID: (Human) 129607, (Rat) 314004, (Mouse) 22169
nucleotide binding
nucleoside diphosphate kinase activity
thymidylate kinase activity
ATP binding
kinase activity
transferase activity
UMP kinase activity
CMP kinase activity
dCMP kinase activity
nucleoside phosphate kinase activity
cytidylate kinase activity
uridylate kinase activity
nucleotide kinase
pyrimidine nucleotide biosynthetic process
dUDP biosynthetic process
dTDP biosynthetic process
dTTP biosynthetic process
nucleoside monophosphate phosphorylation
cellular response to lipopolysaccharide
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
nucleotide phosphorylation
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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