Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: RARERLKNIE RIC
Homology: CNIH2 : Mouse, human identical.CNIH3 : Rat, mouse, human - 11/13 amino acid residues identical.
Cornichon homologs (CNIHs) are a family of AMPA-type glutamate receptor (AMPAR) auxiliary subunits that modulate AMPAR ion channel function and trafficking. Cornichon 2 and 3 (CNIH2/3) are responsible for controlling the export of AMPARs from the endoplasmic reticulum and associate with synaptic AMPARs to modulate channel kinetics. CNIHs are small proteins with three transmembrane domains that directly binds to AMPARs. Overexpression CNIHs and AMPA receptors causes their localization to the Golgi apparatus. CNIH and TARP both compete for the binding to AMPAR subunits GluA2, GluA3, and GluA4 subunits, suggesting both proteins bind to the same site. CNIH2/3 binding to AMPARs is dependent on AMPAR subunit composition and TARPs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CNIH-2; CNIH-3; cornichon 3; Cornichon family AMPA receptor auxiliary protein 2; Cornichon family AMPA receptor auxiliary protein 3; cornichon homolog 2; cornichon homolog 3; Cornichon-like protein; Protein cornichon homolog 2; Protein cornichon homolog 3
Gene Aliases: 2900075G08Rik; CNIH-2; CNIH-3; Cnih2; Cnih3; Cnil; RGD1304930