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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Residues 68-84 of human CNPase.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:100-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with mouse and rat based on 94% sequence homology.
Suggested positive control: antigen standard for CNP (transient overexpression lysate), normal human brain lysate.
CNPase (2',3'-Cyclic Nucleotide 3'-Phosphodiesterase) exists in two forms: 46kDa (CNP1) and 48kDa (CNP2). It is expressed at high levels by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system and is virtual absent in other cell types. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. CNPase gene is localized to chromosome 17q21, very near the BRCA 1 familial breast cancer gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
2', 3' cyclic nucleotide 3' phosphohydrolase; CNP1; CNPase