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Product Details
PA1-84969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant human CNTF
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2292041
Product Specific Information
Reconstitute with 0.1 mL of distilled water. Prior to reconstitution, store at 4ºC. After reconstitution, store undiluted at -20ºC, avoiding freeze/thaw cycles.
This antibody may be used in Western Blotting applications under either reducing or non-reducing conditions.
Rabbit anti Human CTNF antibody recognizes human CNTF (ciliary neurotrophic factor), a 200 amino acid homodimeric neurotrophic and differentiation factor of the CNTF family, which supports the survival and differentiation of several motor neuron types within the nervous system, but also affects other target tissues, including skeletal muscle (Vergara & Ramirez 2005), glial cells, hepatocytes and embryonic stem cells.
Target Information
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ciliary neurotrophic factor; CNTF; H-CNTF
Gene Aliases: CNTF; HCNTF
UniProt ID: (Human) P26441
Entrez Gene ID: (Human) 1270
signal transduction
positive regulation of cell proliferation
positive regulation of gene expression
growth
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of neuron apoptotic process
negative regulation of photoreceptor cell differentiation
regulation of retinal cell programmed cell death
astrocyte activation
muscle organ morphogenesis
neuron development
positive regulation of axon regeneration
ciliary neurotrophic factor-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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