This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: NLPSHVWSST LPAGSSMGTY HNNMTTQSSS LLNTNAYSAG SVFGVPNNMA SCSPTLHPGL STSSSVFGMQ NNLAPSLTTL SHGTTTTSTA
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 84%.
COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 120 kDa linear IgA dermatosis antigen; 120 kDa linear IgA disease antigen; 180 kDa bullous pemphigoid antigen 2; 97 kDa LAD antigen; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa linear IgA disease antigen; alpha 1 type XVII collagen; bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); Bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); Collagen alpha-1(XVII) chain; collagen XVII, alpha-1 polypeptide; collagen, type XVII, alpha 1; LABD97; LAD-1; Linear IgA bullous disease antigen of 97 kDa; Linear IgA disease antigen 1; type XVII collagen alpha-1
Gene Aliases: BA16H23.2; BP180; BPA-2; BPAG2; COL17A1; ERED; LAD-1
UniProt ID: (Human) Q9UMD9
Entrez Gene ID: (Human) 1308
Molecular Function: extracellular matrix structural protein