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Invitrogen
COL1A2 Polyclonal Antibody
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Product Details
PA5-50938
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the N-terminal region of human COL1A2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
COL1A2 Polyclonal Antibody detects endogenous levels of COL1A2 protein.
Target Information
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; Alpha-2 type I collagen; COL1; Collagen alpha-2(I) chain; collagen COL1A2; Collagen I; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain; collagen, type I, alpha 2; osteogenesis imperfecta; procollagen, type I, alpha 2; type I procollagen
Gene Aliases: AA960264; AI325291; Col1a-2; COL1A2; Cola-2; Cola2; OI4; oim
UniProt ID: (Human) P08123, (Mouse) Q01149, (Rat) P02466
Entrez Gene ID: (Human) 1278, (Mouse) 12843, (Rat) 84352
skeletal system development
blood vessel development
transforming growth factor beta receptor signaling pathway
Rho protein signal transduction
blood coagulation
regulation of blood pressure
platelet activation
extracellular matrix organization
collagen fibril organization
collagen catabolic process
odontogenesis
skin morphogenesis
regulation of immune response
leukocyte migration
protein heterotrimerization
cellular response to amino acid stimulus
cellular response to retinoic acid
cellular response to organic substance
response to norepinephrine
cellular response to thyroid hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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