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Product Details
H00084570-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
COL25A1 (AAH36669.1, 1 a.a. approximately 496 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLLKKHAGKG GGREPRSEDP TPAEQHCART MPPCAVLAAL LSVVAVVSCL YLGVKTNDLQ ARIAALESAK GAPSIHLLPD TLDHLKTMVQ EKVERLLAQK SYEHMAKIRI AREAPSECNC PAGPPGKRGK RGRRGESGPP GQPGPQGPPG PKGDKGEQGD QGPRGPLGPP GQKGSIGAPG IPGMNGQKGE PGLPGAVGQN GIPGPKGEPG EQGEKGDAGE NGPKGDTGEK GDPGSSAAGI KGEPGESGRP GQKGEPGLPG LPGLPGIKGE PGFIGPQGEP GLPGLPGTKG ERGEAGPPGR GERGEPGAPG PKGKQGESGT RGPKGSKGDR GEKGDSGAQG PRGPPGQKGD QGATEIIDYN GNLHEALQRI TTLTVTGPPG PPGPQGLQGT KGEQGSPGIP GMDGEQGLKG SKGDMGDPGS QWNERRKRRF WNAGSTGSFY HRPTRPTRSP WPTWPHGTSW TSWTKGSIWL RRKARIPGYR WSYGTPWPCR SQRRKR
Target Information
Alzheimer’s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alzheimer disease amyloid-associated protein; AMY; CLAC-P; Collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component
Gene Aliases: AMY; CFEOM5; CLAC; CLAC-P; CLACP; COL25A1
UniProt ID: (Human) Q9BXS0
Entrez Gene ID: (Human) 84570
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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