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Invitrogen
COL4A5 Polyclonal Antibody
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Product Details
PA5-119042
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Collagen Type IV Alpha 5. The antigen corresponds to amino acid range 1461-1685 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Collagens are highly conserved and are characterized by an uninterrupted Glycine-X-Y triplet repeat. Col1, the fibrillar collagen found in most connective tissues, is the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Col2, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia. Col3 is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome type IV, aortic and arterial aneurysms. Col4 is a major consitiuent of the basement membranes along with laminins and enactins. It is composed of alpha 1 IV chain and alpha 2 IV chain in 2:1 ratio. Col4 antibodies are useful in detecting the loss of parts of basement membrane in carcinomas. Col5 is found in tissues containing Col1 and appears to regulate the assembly of heterotypic fibers composed of both Col1 and Col5. Col5 is closely related to type XI collagen; mutations in this gene are associated with Ehlers-Danlos syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CO4A5; Collagen alpha-5(IV) chain; collagen IV, alpha-5 polypeptide; collagen of basement membrane, alpha-5 chain; collagen type IV alpha 5 chain; collagen type IV alpha5 chain; collagen, type IV, alpha 5; dA149D17.3; dA24A23.1; procollagen type IV alpha 5; procollagen, type IV, alpha 5; unnamed protein product
Gene Aliases: ASLN; ATS; ATS1; CA54; COL4A5; RGD1565499
UniProt ID: (Human) P29400, (Mouse) Q63ZW6
Entrez Gene ID: (Human) 1287, (Pig) 100737091, (Mouse) 12830, (Rat) 363457
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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