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Invitrogen
COMMD1 Polyclonal Antibody
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Product Details
PA5-77153
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human COMMD1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COMM domain-containing protein 1; copper metabolism (Murr1) domain containing 1; copper metabolism domain containing 1; copper metabolism gene MURR1; Protein Murr1; U2af1-rs1 region 1
Gene Aliases: AI256843; C2orf5; COMMD1; MURR1; U2/Mu
UniProt ID: (Human) Q8N668, (Mouse) Q8BNL9
Entrez Gene ID: (Human) 150684, (Rat) 289831, (Mouse) 17846
copper ion binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
identical protein binding
protein homodimerization activity
phosphatidylinositol-3,4-bisphosphate binding
phosphatidic acid binding
phosphatidylinositol-3,5-bisphosphate binding
sodium channel inhibitor activity
metal ion binding
transcription, DNA-templated
Golgi to plasma membrane transport
protein transport
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
regulation of proteasomal ubiquitin-dependent protein catabolic process
plasma membrane to endosome transport
copper ion homeostasis
negative regulation of sodium ion transmembrane transport
negative regulation of protein localization to cell surface
protein destabilization
negative regulation of hypoxia-inducible factor-1alpha signaling pathway
regulation of transcription, DNA-templated
transport
cellular copper ion homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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