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Invitrogen
COMP Polyclonal Antibody
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FIGURE: 1 / 3
COMP Antibody (PA5-95547) in IHC (P)
Immunohistochemistry analysis of COMP in paraffin-embedded human cholangiocarcinoma tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with COMP polyclonal antibody (Product # PA5-95547) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Compl... View More
Product Details
PA5-95547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human COMP recombinant protein (Position: Q505-A757).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human Hacat whole cell, human CACO-2 whole cell, human 293T whole cell, rat cartilage tissue, mouse cartilage tissue. IHC: mouse knee-joint tissue, rat knee-joint tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
COMP is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); COMP; MGC131819; MGC149768; multiple epiphyseal dysplasia; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); Thrombospondin-5; Thrombospondin5; TSP 5; TSP5; unnamed protein product
Gene Aliases: COMP; CTS2; EDM1; EPD1; MED; PSACH; THBS5; TSP-5; TSP5
UniProt ID: (Human) P49747, (Mouse) Q9R0G6, (Rat) P35444
Entrez Gene ID: (Human) 1311, (Mouse) 12845, (Rat) 25304
growth plate cartilage development
apoptotic process
cell adhesion
extracellular matrix organization
negative regulation of apoptotic process
limb development
skeletal system development
ossification
chondrocyte development
endochondral bone growth
response to unfolded protein
blood coagulation
protein secretion
organ morphogenesis
regulation of gene expression
vascular smooth muscle contraction
protein processing
collagen fibril organization
bone mineralization
regulation of bone mineralization
BMP signaling pathway
multicellular organism growth
chondrocyte proliferation
tendon development
skin development
artery morphogenesis
musculoskeletal movement
neuromuscular process
cartilage development
protein homooligomerization
muscle cell development
bone morphogenesis
platelet aggregation
cellular senescence
vascular smooth muscle cell development
bone growth
negative regulation of hemostasis
positive regulation of chondrocyte proliferation
cartilage homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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