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Invitrogen
COMP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96435
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.43 mg/mL
Amount
243 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: SW620, U-251MG, HepG2, MCF7, Mouse skeletal muscle; Cellular Location: extracellular matrix, extracellular space
Target Information
COMP is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); MGC131819; MGC149768; multiple epiphyseal dysplasia; pentameric glycoprotein; extracellular matrix protein; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); thrombospondin-5; Thrombospondin5; TSP 5; unnamed protein product
Gene Aliases: CTS2; EDM1; EPD1; MED; PSACH; THBS5; TSP-5; TSP5
UniProt ID: (Human) P49747, (Rat) P35444, (Mouse) Q9R0G6
Entrez Gene ID: (Human) 1311, (Rat) 25304, (Mouse) 12845
skeletal system development
cell adhesion
organ morphogenesis
collagen fibril organization
negative regulation of apoptotic process
protein homooligomerization
limb development
cartilage homeostasis
ossification
chondrocyte development
endochondral bone growth
growth plate cartilage development
apoptotic process
response to unfolded protein
blood coagulation
protein secretion
regulation of gene expression
vascular smooth muscle contraction
protein processing
bone mineralization
regulation of bone mineralization
BMP signaling pathway
multicellular organism growth
chondrocyte proliferation
tendon development
skin development
artery morphogenesis
musculoskeletal movement
neuromuscular process
cartilage development
muscle cell development
bone morphogenesis
platelet aggregation
cellular senescence
vascular smooth muscle cell development
bone growth
negative regulation of hemostasis
positive regulation of chondrocyte proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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