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Invitrogen
COMP Recombinant Rabbit Monoclonal Antibody (2H3R5)
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FIGURE: 1 / 1
COMP Antibody (MA5-51253) in WB
Western blot analysis of COMP in various lysates. Samples were incubated with COMP Recombinant monoclonal antibody (Product # MA5-51253) using a dilution of 1:2,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
MA5-51253
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2H3R5
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human COMP (NP_000086.2).
Conjugate
Form
Liquid
Concentration
0.56 mg/mL
Amount
56 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELLRQQVREI TFLKNTVMEC DACGMQQSVR TGLPSVRPLL HCAPGFCFPG VACIQTESGA RCGPCPAGFT GNGSHCTDVN ECNAHPCFPR VRCINTSPGF R
Target Information
COMP is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); COMP; MGC131819; MGC149768; multiple epiphyseal dysplasia; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); Thrombospondin-5; Thrombospondin5; TSP 5; TSP5; unnamed protein product
Gene Aliases: COMP; CTS2; EDM1; EPD1; MED; PSACH; THBS5; TSP-5; TSP5
UniProt ID: (Human) P49747, (Mouse) Q9R0G6, (Rat) P35444
Entrez Gene ID: (Human) 1311, (Mouse) 12845, (Rat) 25304
growth plate cartilage development
apoptotic process
cell adhesion
extracellular matrix organization
negative regulation of apoptotic process
limb development
skeletal system development
ossification
chondrocyte development
endochondral bone growth
response to unfolded protein
blood coagulation
protein secretion
organ morphogenesis
regulation of gene expression
vascular smooth muscle contraction
protein processing
collagen fibril organization
bone mineralization
regulation of bone mineralization
BMP signaling pathway
multicellular organism growth
chondrocyte proliferation
tendon development
skin development
artery morphogenesis
musculoskeletal movement
neuromuscular process
cartilage development
protein homooligomerization
muscle cell development
bone morphogenesis
platelet aggregation
cellular senescence
vascular smooth muscle cell development
bone growth
negative regulation of hemostasis
positive regulation of chondrocyte proliferation
cartilage homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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