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Invitrogen
COPG Polyclonal Antibody
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FIGURE: 1 / 1
COPG Antibody (PA5-87979) in WB
Western blot analysis of COPG in extracts of various cell lines. Samples were incubated with COPG Polyclonal antibody (Product # PA5-87979) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-87979
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 555-874 of human COPG1 (NP_0572121)
Conjugate
Form
Liquid
Concentration
0.12 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IPGLERALQQ YTLEPSEKPF DLKSVPLATA PMAEQRTEST PITAVKQPEK VAATRQEIFQ EQLAAVPEFR GLGPLFKSSP EPVALTESET EYVIRCTKHT FTNHMVFQFD CTNTLNDQTL ENVTVQMEPT EAYEVLCYVP ARSLPYNQPG TCYTLVALPK EDPTAVACTF SCMMKFTVKD CDPTTGETDD EGYEDEYVLE DLEVTVADHI QKVMKLNFEA AWDEVGDEFE KEETFTLSTI KTLEEAVGNI VKFLGMHPCE RSDKVPDNKN THTLLLAGVF RGGHDILVRS RLLLLDTVTM QVTARSLEEL PVDIILASVG; Positive Samples: HepG2, A-375, BT-474, Mouse liver, Mouse kidney, Rat kidney; Cellular Location: COPI-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein
Target Information
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coat protein gamma-cop; coatomer protein complex, subunit gamma 1; coatomer subunit gamma; Coatomer subunit gamma-1; Gamma-1-coat protein; Gamma-1-COP; gamma-coat protein; gamma-COP
Gene Aliases: AU019265; BC056168; COPG; COPG1; D6Ertd71e; D6Wsu16e
UniProt ID: (Human) Q9Y678, (Mouse) Q9QZE5, (Rat) Q4AEF8
Entrez Gene ID: (Human) 22820, (Mouse) 54161, (Rat) 297428
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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