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COX1 Polyclonal Antibody
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Product Details
OSC00197W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 400-450 of human COX1 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: COXI.
Target Information
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: COX-1; COX-1b1; COX-1b2; COX-1b3; cyclooxygenase 3; Cyclooxygenase-1; P PGG/HS; PGH synthase 1; PHS 1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); unnamed protein product
Gene Aliases: Cox-1; Cox-3; COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS 1; PHS1; PTGHS; PTGS1
UniProt ID: (Human) P23219, (Mouse) P22437
Entrez Gene ID: (Human) 5742, (Rat) 24693, (Mouse) 19224
peroxidase activity
prostaglandin-endoperoxide synthase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
heme binding
metal ion binding
dioxygenase activity
lipid binding
oxygenase
prostaglandin biosynthetic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
response to oxidative stress
regulation of blood pressure
cyclooxygenase pathway
regulation of cell proliferation
cellular oxidant detoxification
inflammatory response
aging
learning
memory
response to organonitrogen compound
negative regulation of norepinephrine secretion
sensory perception of pain
negative regulation of epinephrine secretion
maintenance of blood-brain barrier
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
response to corticosterone
oxidation-reduction process
response to fatty acid
keratinocyte differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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