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Invitrogen
CPEB3 Polyclonal Antibody
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FIGURE: 1 / 3
CPEB3 Antibody (PA5-90443) in IHC (P)
Immunohistochemistry analysis of CPEB3 in paraffin-embedded mouse brain. Samples were incubated with CPEB3 Polyclonal antibody (Product # PA5-90443) using a dilution of 1:300 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-90443
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
2.9 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TFSPQIGLAQ TQHHQQPPPP APAPQPAQPA QPPQAQPPQQ RRSPASPSQA PYAQRSAAAA YGHQPIMTSK PSSSSAVAAA AAAAAASSAS SSWNTHQSVN AAWSAPSNPW GGLQAGRDPR RAVGVGVGVG VGVPSPLNPI SPLKKPFSSN VIAPPKFPRA APLTSKSWME DNAFRTDNGN NLLPFQDRSR PYDTFNLHSL ENSLMDMIRT DHEPLKGKHY PPSGPPMSFA DIMWRNHFAG RMGINFHHPG T; Positive Samples: Mouse heart, Mouse kidney, Rat heart
Target Information
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation. Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception. Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation. Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CPE-binding protein 3; CPE-BP3; cytoplasmic polyadenylation element binding protein 3; Cytoplasmic polyadenylation element-binding protein 3; hCPEB-3
Gene Aliases: 4831444O18Rik; CPE-BP3; CPEB3; KIAA0940; mKIAA0940; RGD1564670
UniProt ID: (Human) Q8NE35, (Mouse) Q7TN99
Entrez Gene ID: (Human) 22849, (Rat) 309510, (Mouse) 208922
nucleotide binding
translation repressor activity, nucleic acid binding
RNA binding
mRNA 3'-UTR binding
protein binding
translation factor activity, RNA binding
RNA stem-loop binding
mRNA 3'-UTR AU-rich region binding
ribosome binding
poly(A) RNA binding
nucleic acid binding
mRNA polyadenylation factor
negative regulation of transcription from RNA polymerase II promoter
translation
long-term memory
negative regulation of translation
positive regulation of translation
regulation of synaptic plasticity
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
regulation of dendritic spine development
positive regulation of dendritic spine development
3'-UTR-mediated mRNA destabilization
cellular response to amino acid stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of cytoplasmic translational elongation
positive regulation of mRNA polyadenylation
negative regulation of cytoplasmic translation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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