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Proteintech
CRH/CRF Polyclonal Antibody
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Product Details
26848-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRH/CRF fusion protein Ag25226
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
90 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SEQPQQPQAR PVLLRMGEEY FLRLGNLNKS PAAPLSPASS LLAGGSGSRP SPEQATANFF RVLLQQLLLP RRSLDSPAAL AERGARNALG GHQEAPERER RSEE
Target Information
Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Corticoliberin; corticotropin releasing factor; Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF; unnamed protein product
Gene Aliases: CRF; CRH; CRH1; Gm1347
UniProt ID: (Human) P06850, (Rat) P01143, (Mouse) Q8CIT0
Entrez Gene ID: (Human) 1392, (Rat) 81648, (Mouse) 12918
synaptic transmission, dopaminergic
negative regulation of systemic arterial blood pressure
glucocorticoid biosynthetic process
inflammatory response
signal transduction
chemical synaptic transmission
female pregnancy
parturition
learning or memory
steroid metabolic process
positive regulation of cell proliferation
associative learning
hormone-mediated apoptotic signaling pathway
response to xenobiotic stimulus
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of circadian sleep/wake cycle, wakefulness
regulation of serotonin secretion
diterpenoid metabolic process
hypothalamus development
lung development
adrenal gland development
negative regulation of epinephrine secretion
negative regulation of luteinizing hormone secretion
locomotory exploration behavior
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to immobilization stress
response to cocaine
negative regulation of circadian sleep/wake cycle, REM sleep
response to estrogen
response to ethanol
response to ether
response to pain
ion homeostasis
neuron apoptotic process
response to corticosterone
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
long-term synaptic potentiation
positive regulation of digestive system process
negative regulation of glucagon secretion
cellular response to cocaine
cellular response to dexamethasone stimulus
positive regulation of calcium ion import
response to alcohol
positive regulation of cAMP/PKA signal transduction
response to aldosterone
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of corticosterone secretion
positive regulation of behavioral fear response
positive regulation of protein phosphorylation
positive regulation of cell death
positive regulation of cAMP biosynthetic process
response to drug
negative regulation of blood pressure
negative regulation of cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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