Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-145052
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 1-51. Recombinant protein control fragment (Product #RP-109711).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3091764
Product Specific Information
Immunogen sequence: MDAALLHSLL EANCSLALAE ELLLDGWGPP LDPEGPYSYC NTTLDQIGTC W
Antigen sequence identity: Mouse 92%; Rat 94%
Target Information
Corticotropin-releasing hormone (CRH; 122560) is a 41-amino acid peptide synthesized in the hypothalamus, and play a role in the neuroregulation, responses to stress and immune challenge. Corticotropin Releasing Factor Receptor 2 (CRHR2) was the receptor of CRH. The sepression of CRHR2 has been reported in various regions of the brain as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Corticotropin-releasing factor receptor 2; Corticotropin-releasing hormone receptor 2; CRF-R-2; CRF2 receptor, beta isoform; CRH receptor 2 variant B; CRH-R-2; CRH-R2; Crh2 receptor
Gene Aliases: CRF-RB; CRF2; CRF2R; CRFR2; CRH2R; CRHR2; HM-CRF
UniProt ID: (Human) Q13324
Entrez Gene ID: (Human) 1395
actin filament organization
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of heart rate
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of serotonin secretion
sensory perception of pain
cerebellum development
hypothalamus development
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
positive regulation of interleukin-6 production
negative regulation of epinephrine secretion
positive regulation of stress-activated MAPK cascade
negative regulation of luteinizing hormone secretion
gastric motility
catecholamine biosynthetic process
positive regulation of blood pressure
negative regulation of follicle-stimulating hormone secretion
skeletal muscle tissue growth
positive regulation of NF-kappaB transcription factor activity
long-term synaptic potentiation
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
cellular response to corticotropin-releasing hormone stimulus
cellular response to glucocorticoid stimulus
negative regulation of calcium ion import
negative regulation of feeding behavior
negative regulation of defecation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support