CRLF1 encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome.
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Protein Aliases: class I cytokine receptor; CLF-1; CRLM-3; cytokine receptor like molecule 3; Cytokine receptor-like factor 1; Cytokine receptor-like molecule 3; cytokine type 1 receptor CRLP-1; Cytokine-like factor 1; Novel cytokine receptor 6; NR6; ZcytoR5
Gene Aliases: CISS; CISS1; CLF; CLF-1; CRLF1; CRLM3; NR6; NR6.1; UNQ288/PRO327; zcytor5
Molecular Function: transmembrane signal receptor