PA5-31150 targets zeta Crystallin in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-31150 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 131 of Human zeta Crystallin.
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Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist.
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Protein Aliases: crystallin, zeta (quinone reductase); NADPH:quinone reductase; Quinone oxidoreductase; quinone reductase; Zeta-crystallin
Gene Aliases: CRYZ; Sez9