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Invitrogen
CSB Polyclonal Antibody
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Product Details
PA5-111673
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CSB. Recombinant protein control fragment (Product #RP-108583).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TLSLHEITDL LETDDSIEAS AIVIQPPENA TAPVSDEESG DEEGGTINNL PGSLLHTAAY LIQDGSDAES DSDDPSYAPK DDSPDEVPST FTVQQPPPSR RRKMTKILCK WKKADLTVQP VAGRVTAPPN DFFTVMRTPT E
Highest antigen sequence indentity to the following orthologs: Mouse - 25%, Rat - 25%.
Target Information
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase ERCC6; Chimeric CSB-PGBD3 protein; Chimeric ERCC6-PGBD3 protein; Cockayne syndrome group B protein; Cockayne syndrome protein CSB; DNA excision repair protein ERCC-6; excision repair cross-complementation group 6; excision repair cross-complementing rodent repair deficiency, complementation group 6; unnamed protein product
Gene Aliases: ARMD5; CKN2; COFS; COFS1; CSB; CSB-PGBD3; ERCC6; POF11; RAD26; UVSS1
UniProt ID: (Human) P0DP91
Entrez Gene ID: (Human) 2074
nucleotide binding
DNA binding
DNA helicase activity
chromatin binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
hydrolase activity
ATPase activity
protein tyrosine kinase activator activity
sequence-specific DNA binding
RNA polymerase binding
chromatin-protein adaptor activity
ATP-dependent chromatin remodeler activity
ATP-dependent DNA damage sensor activity
single strand break repair
DNA damage checkpoint
response to superoxide
positive regulation of defense response to virus by host
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair
pyrimidine dimer repair
chromatin remodeling
transcription elongation from RNA polymerase I promoter
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
response to oxidative stress
JNK cascade
nervous system development
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
response to toxic substance
response to X-ray
response to UV-B
response to gamma radiation
positive regulation of gene expression
protein ubiquitination
neurogenesis
neuron differentiation
neuron projection development
regulation of DNA-templated transcription, elongation
positive regulation of DNA-templated transcription, elongation
positive regulation of peptidyl-serine phosphorylation of STAT protein
regulation of transcription elongation from RNA polymerase II promoter
multicellular organism growth
DNA protection
photoreceptor cell maintenance
positive regulation of DNA repair
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
positive regulation of transcription initiation from RNA polymerase II promoter
protein localization to chromatin
double-strand break repair via classical nonhomologous end joining
positive regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair via nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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