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Invitrogen
CSB Polyclonal Antibody
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FIGURE: 1 / 1
CSB Antibody (PA5-79218) in WB
Western blot analysis of CSB in, Lane 1: human Hela whole cell lysates, Lane 2: human A431 whole cell lysates, Lane 3: human Siha whole cell lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. The membrane was blocked with 5% non-fat milk/TBS for 1. 5 hour at RT. The membrane was... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79218
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human CSB (160-205aa QAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVK).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human A431 whole cell, human Siha whole cell.
Target Information
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase ERCC6; Chimeric CSB-PGBD3 protein; Chimeric ERCC6-PGBD3 protein; Cockayne syndrome group B protein; cockayne syndrome protein CSB; excision repair cross-complementation group 6; excision repair cross-complementing rodent repair deficiency, complementation group 6; unnamed protein product
Gene Aliases: ARMD5; CKN2; COFS; COFS1; CSB; CSB-PGBD3; POF11; RAD26; UVSS1
UniProt ID: (Human) P0DP91
Entrez Gene ID: (Human) 2074
DNA binding
DNA helicase activity
chromatin binding
protein binding
ATP binding
DNA-dependent ATPase activity
ATPase activity
protein tyrosine kinase activator activity
sequence-specific DNA binding
RNA polymerase binding
chromatin-protein adaptor activity
ATP-dependent chromatin remodeler activity
ATP-dependent DNA damage sensor activity
single strand break repair
DNA damage checkpoint
positive regulation of defense response to virus by host
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair
chromatin remodeling
transcription from RNA polymerase II promoter
response to oxidative stress
positive regulation of gene expression
neurogenesis
neuron differentiation
neuron projection development
regulation of DNA-templated transcription, elongation
positive regulation of DNA-templated transcription, elongation
positive regulation of peptidyl-serine phosphorylation of STAT protein
regulation of transcription elongation from RNA polymerase II promoter
DNA protection
positive regulation of DNA repair
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
protein localization to chromatin
double-strand break repair via classical nonhomologous end joining
positive regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair via nonhomologous end joining
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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