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Invitrogen
CSF1R Polyclonal Antibody
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FIGURE: 1 / 1
CSF1R Antibody (PA5-17538) in WB
Western blot analysis of M-CSF Receptor in extracts from GDM-1 cells, untreated or lambda phosphatase-treated, using M-CSF Receptor polyclonal antibody (Product # PA5-17538) using a Phospho-M-CSF Receptor pTyr723 polyclonal antibody (upper) or M-CSF Receptor antibody (lower).
Product Details
PA5-17538
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to carboxy-terminal residues of human M-CSF receptor
Conjugate
Form
Liquid
Concentration
97 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-fms; CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; Proto-oncogene c-Fms; proto-oncogene fms
Gene Aliases: AI323359; C-FMS; CD115; CSF-1R; CSF1R; Csfmr; CSFR; Fim-2; FIM2; FMS; HDLS; M-CSF-R; M-CSFR
UniProt ID: (Human) P07333, (Mouse) P09581
Entrez Gene ID: (Human) 1436, (Mouse) 12978
macrophage colony-stimulating factor receptor activity
ATP binding
protein phosphatase binding
cytokine binding
protein homodimerization activity
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
positive regulation of protein phosphorylation
inflammatory response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
axon guidance
skeletal muscle tissue development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
olfactory bulb development
forebrain neuron differentiation
hemopoiesis
monocyte differentiation
macrophage differentiation
osteoclast differentiation
positive regulation of cell migration
ruffle organization
cellular response to macrophage colony-stimulating factor stimulus
macrophage colony-stimulating factor signaling pathway
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of apoptotic process
innate immune response
regulation of bone resorption
cell-cell junction maintenance
positive regulation of osteoclast differentiation
phosphatidylinositol metabolic process
protein autophosphorylation
phosphatidylinositol-mediated signaling
mammary gland duct morphogenesis
positive regulation of protein tyrosine kinase activity
positive regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
positive regulation of protein serine/threonine kinase activity
positive regulation of chemokine secretion
positive regulation of cell motility
regulation of actin cytoskeleton reorganization
immune system process
protein phosphorylation
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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