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Invitrogen
CSF1R Polyclonal Antibody
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FIGURE: 1 / 1
CSF1R Antibody (PA5-19364) in WB
Western blot analysis of CSF1R using CSF1R Polyclonal Antibody (Product # PA5-19364) in Lane A: HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human CSF1R with C-terminal MYC tag probed with CSF1R Polyclonal (0.5 µg/mL). Lane B: Mock-transfected HEK293 probed with CSF1R Polyclonal (1 mg/mL). Lane C: transfected HEK293 lysate probed with anti-MYC Tag (1:1,000). Primary incubations were for 1 hour. Detected by chemiluminescence.
Product Details
PA5-19364
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (KNIHLEKKYVR) corresponding to the internal amino acids of CSF1R (aa 700-711).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; Proto-oncogene c-Fms; transmembrane protein; unnamed protein product
Gene Aliases: BANDDOS; C-FMS; CD115; CSF-1R; CSF1R; CSFR; FIM2; FMS; GPSC; HDLS; HDLS1; M-CSF-R
UniProt ID: (Human) P07333
Entrez Gene ID: (Human) 1436
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
macrophage colony-stimulating factor receptor activity
protein binding
ATP binding
kinase activity
transferase activity
growth factor binding
protein phosphatase binding
cytokine binding
protein homodimerization activity
positive regulation of protein phosphorylation
immune system process
myeloid leukocyte differentiation
response to ischemia
response to stress
inflammatory response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
axon guidance
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
anatomical structure morphogenesis
positive regulation of macrophage chemotaxis
cell migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
olfactory bulb development
forebrain neuron differentiation
regulation of cell morphogenesis
hemopoiesis
monocyte differentiation
macrophage differentiation
osteoclast differentiation
positive regulation of cell migration
ruffle organization
positive regulation of chemokine production
regulation of actin cytoskeleton organization
cellular response to macrophage colony-stimulating factor stimulus
macrophage colony-stimulating factor signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of apoptotic process
regulation of MAPK cascade
positive regulation by host of viral process
innate immune response
regulation of bone resorption
cell-cell junction maintenance
protein autophosphorylation
animal organ development
positive regulation of protein kinase B signaling
mammary gland duct morphogenesis
positive regulation of protein tyrosine kinase activity
microglial cell proliferation
positive regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
positive regulation of macrophage proliferation
regulation of macrophage migration
positive regulation of cell motility
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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