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Invitrogen
CSF2 Polyclonal Antibody
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Product Details
PA5-115052
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CSF2(Accession P04141), corresponding to amino acid residues G82-L132.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CSF2.
Target Information
The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; GM-CSF; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; Granulocyte-macrophage colony-stimulating factor; granulocyte/macrophage colony-stimulating factor; M-GM-CSF; MGC131935; MGC138897; MGC151255; MGC151257; molgramostim; Molgramostin; put. GM-CSF; Sargramostim
Gene Aliases: CSF; CSF2; Csfgm; Gm-CSf; GMCSF; MGI-IGM
UniProt ID: (Human) P04141, (Mouse) P01587, (Rat) P48750
Entrez Gene ID: (Human) 1437, (Mouse) 12981, (Rat) 116630
histamine secretion
embryonic placenta development
immune response
signal transduction
JAK-STAT cascade
cell proliferation
positive regulation of cell proliferation
regulation of signal transduction
regulation of gene expression
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
myeloid cell differentiation
neutrophil differentiation
monocyte differentiation
macrophage differentiation
positive regulation of cell migration
positive regulation of interleukin-23 production
response to silicon dioxide
response to fluid shear stress
granulocyte-macrophage colony-stimulating factor signaling pathway
epithelial fluid transport
regulation of cell proliferation
myeloid dendritic cell differentiation
regulation of circadian sleep/wake cycle, sleep
negative regulation of transcription, DNA-templated
regulation of developmental process
positive regulation of leukocyte proliferation
cellular response to lipopolysaccharide
positive regulation of podosome assembly
cellular response to granulocyte macrophage colony-stimulating factor stimulus
dendritic cell differentiation
receptor signaling pathway via STAT
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
macrophage activation
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of DNA replication
negative regulation of cytolysis
positive regulation of macrophage differentiation
epithelial cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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