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Product Details
17720-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CSK Fusion Protein Ag12103 (83-450 aa encoded by BC106073)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: FHGKITREQ AERLLYPPET GLFLVRESTN YPGDYTLCVS CDGKVEHYRI MYHASKLSID EEVYFENLMQ LVEHYTSDAD GLCTRLIKPK VMEGTVAAQD EFYRSGWALN MKELKLLQTI GKGEFGDVML GDYRGNKVAV KCIKNDATAQ AFLAEASVMT QLRHSNLVQL LGVIVEEKGG LYIVTEYMAK GSLVDYLRSR GRSVLGGDCL LKFSLDVCEA MEYLEGNNFV HRDLAARNVL VSEDNVAKVS DFGLTKEASS TQDTGKLPVK WTAPEALREK KFSTKSDVWS FGILLWEIYS FGRVPYPRIP LKDVVPRVEK GYKMDAPDGC PPAVYEVMKN CWHLDAAMRP SFLQLREQLE HIKTHELHL (83-450 aa encoded by BC106073)
Target Information
C-terminal Src kinase (CSK) is a non-receptor protein tyrosine kinase that plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-Src kinase; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK
Gene Aliases: CSK
UniProt ID: (Human) P41240
Entrez Gene ID: (Human) 1445
regulation of cytokine production
adaptive immune response
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
central nervous system development
brain development
negative regulation of cell proliferation
negative regulation of low-density lipoprotein particle clearance
cell migration
cell differentiation
T cell costimulation
negative regulation of interleukin-6 production
negative regulation of kinase activity
adherens junction organization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of Golgi to plasma membrane protein transport
positive regulation of MAP kinase activity
innate immune response
negative regulation of bone resorption
oligodendrocyte differentiation
negative regulation of phagocytosis
T cell receptor signaling pathway
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to peptide hormone stimulus
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
protein C-terminus binding
kinase activity
protein phosphatase binding
protein kinase A catalytic subunit binding
identical protein binding
metal ion binding
proline-rich region binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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