Immunogen sequence: FHGKITREQ AERLLYPPET GLFLVRESTN YPGDYTLCVS CDGKVEHYRI MYHASKLSID EEVYFENLMQ LVEHYTSDAD GLCTRLIKPK VMEGTVAAQD EFYRSGWALN MKELKLLQTI GKGEFGDVML GDYRGNKVAV KCIKNDATAQ AFLAEASVMT QLRHSNLVQL LGVIVEEKGG LYIVTEYMAK GSLVDYLRSR GRSVLGGDCL LKFSLDVCEA MEYLEGNNFV HRDLAARNVL VSEDNVAKVS DFGLTKEASS TQDTGKLPVK WTAPEALREK KFSTKSDVWS FGILLWEIYS FGRVPYPRIP LKDVVPRVEK GYKMDAPDGC PPAVYEVMKN CWHLDAAMRP SFLQLREQLE HIKTHELHL (83-450 aa encoded by BC106073)
C-terminal Src kinase (CSK) is a non-receptor protein tyrosine kinase that plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
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Protein Aliases: C-Src kinase; MGC117393; Protein-tyrosine kinase CYL; Tyrosine-protein kinase CSK
Gene Aliases: CSK
UniProt ID: (Human) P41240
Entrez Gene ID: (Human) 1445