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Proteintech
CSN2 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-10969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CSN2 fusion protein Ag1415
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSDMEDDFM CDDEEDYDLE YSEDSNSEPN VDLENQYYNS KALKEDDPKA ALSSFQKVLE LEGEKGEWGF KALKQMIKIN FKLTNFPEMM NRYKQLLTYI RSAVTRNYSE KSINSILDYI STSKQMDLLQ EFYETTLEAL KDAKNDRLWF KTNTKLGKLY LEREEYGKLQ KILRQLHQSC QTDDGEDDLK KGTQLLEIYA LEIQMYTAQK NNKKLKALYE QSLHIKSAIP HPLIMGVIRE CGGKMHLREG EFEKAHTDFF EAFKNYDESG SPRRTTCLKY LVLANMLMKS GINPFDSQEA KPYKNDPEIL AMTNLVSAYQ NNDITEFEKI LKTNHSNIMD DPFIREHIEE LLRNIRTQVL IKLIKPYTRI HIPFISKELN IDVADVESLL VQCILDNTIH GRIDQVNQLL ELDHQKRGGA RYTALDKWTN QLNSLNQAVV SKLA
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alien homolog; alien-like; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; corepressor for nuclear hormone receptors; JAB1-containing signalosome subunit 2; SGN2; signalosome subunit 2; subunit of the signalosome complex; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15; TRIP15; unnamed protein product
Gene Aliases: AI315723; ALIEN; C85265; COPS2; CSN2; SGN2; TRIP-15; TRIP15
UniProt ID: (Human) P61201, (Mouse) Q9R249
Entrez Gene ID: (Human) 9318, (Mouse) 12848
negative regulation of transcription from RNA polymerase II promoter
cell proliferation
neuron differentiation
skeletal muscle cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
protein deneddylation
inner cell mass cell proliferation
trophectodermal cell proliferation
transcription from RNA polymerase II promoter
protein phosphorylation
signal transduction
protein neddylation
regulation of protein neddylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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