Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: KYSEVFEAI NITNNERVVV KILKPVKKKK IKREVKILEN LRGGTNIIKL IDTVKDPVSK TPALVFEYIN NTDFKQLYQI LTDFDIRFYM YELLKALDYC HSKGIMHRDV KPHNVMIDHQ QKKLRLIDWG LAEFYHPAQE YNVRVASRYF KGPELLVDYQ MYDYSLDMWS LGCMLASMIF RREPFFHGQD NYDQLVRIAK VLGTEELYGY LKKYHIDLDP HFNDILGQHS RKRWENFIHS ENRHLVSPEA LDLLDKLLRY DHQQRLTAKE AMEHPYFYPV VKEQSQPCAD NAVLSSGLTA AR (50-350 aa encoded by BC008812)
Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
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Protein Aliases: casein kinase 2 alpha; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide; Casein kinase II subunit alpha'; CK II alpha'
Gene Aliases: CK2A2; CK2alpha'; CSNK2A1; CSNK2A2
UniProt ID: (Human) P19784
Entrez Gene ID: (Human) 1459
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