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Invitrogen
CSNK2A2 Polyclonal Antibody
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FIGURE: 1 / 2
CSNK2A2 Antibody (PA5-102442) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded CSNK2A2 in rat lung tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with CSNK2A2 polyclonal antibody (Product # PA5-102442) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-102442
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CSNK2A2(Accession P19784), corresponding to amino acid residues A5-F55.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CSNK2A2.
Target Information
Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 2 alpha; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide; Casein kinase II subunit alpha'; casein kinase II, alpha 2, polypeptide; CK II alpha'
Gene Aliases: 1110035J23Rik; C77789; CK2; CK2A2; CK2alpha'; CSNK2A1; CSNK2A2
UniProt ID: (Human) P19784, (Mouse) O54833
Entrez Gene ID: (Human) 1459, (Mouse) 13000, (Rat) 307641
double-strand break repair
apoptotic process
cellular response to DNA damage stimulus
spermatogenesis
Wnt signaling pathway
cerebral cortex development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein catabolic process
regulation of cell cycle
liver regeneration
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
regulation of chromosome separation
negative regulation of apoptotic signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
cell cycle
phosphorylation
mitotic spindle checkpoint
regulation of mitophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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