FIGURE: 1 / 13
Immunogen sequence: MGSSHLLNK GLPLGVRPPI MNGPLHPRPL VALLDGRDCT VEMPILKDVA TVAFCDAQST QEIHEKVLNE AVGALMYHTI TLTREDLEKF KALRIIVRIG SGFDNIDIKS AGDLGIAVCN VPAASVEETA DSTLCHILNL YRRATWLHQA LREGTRVQSV EQIREVASGA ARIRGETLGI IGLGRVGQAV ALRAKAFGFN VLFYDPYLSD GVERALGLQR VSTLQDLLFH SDCVTLHCGL NEHNHHLIND FTVKQMRQGA FLVNTARGGL VDEKALAQAL KEGRIRGAAL DVHESEPFSF SQGPLKDAPN LICTPHAAWY SEQASIEMRE EAAREIRRAI TGRIPDSLKN CVNKDHLTAA THWASMDPAV VHPELNGAAY RYPPGVVGVA PTGIPAAVEG IVPSAMSLSH GLPPVAHPPH APSPGQTVKP EADRDHASDQ L (1-440 aa encoded by BC011655)
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
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Protein Aliases: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; CtBP1; MGC104684
Gene Aliases: BARS; CTBP; CTBP1; CtBP1-L; CtBP1-S; CtBP3/BARS; D4S115h; D5H4S115; D5H4S115E
Molecular Function: transcription cofactor