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Proteintech

CTBP1 Polyclonal Antibody

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View all (22) CtBP1 antibodies

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CTBP1 Polyclonal Antibody

Product Details

10972-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:500
View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CTBP1 Fusion Protein Ag1425 (1-440 aa encoded by BC011655)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Amount

25.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGSSHLLNK GLPLGVRPPI MNGPLHPRPL VALLDGRDCT VEMPILKDVA TVAFCDAQST QEIHEKVLNE AVGALMYHTI TLTREDLEKF KALRIIVRIG SGFDNIDIKS AGDLGIAVCN VPAASVEETA DSTLCHILNL YRRATWLHQA LREGTRVQSV EQIREVASGA ARIRGETLGI IGLGRVGQAV ALRAKAFGFN VLFYDPYLSD GVERALGLQR VSTLQDLLFH SDCVTLHCGL NEHNHHLIND FTVKQMRQGA FLVNTARGGL VDEKALAQAL KEGRIRGAAL DVHESEPFSF SQGPLKDAPN LICTPHAAWY SEQASIEMRE EAAREIRRAI TGRIPDSLKN CVNKDHLTAA THWASMDPAV VHPELNGAAY RYPPGVVGVA PTGIPAAVEG IVPSAMSLSH GLPPVAHPPH APSPGQTVKP EADRDHASDQ L (1-440 aa encoded by BC011655)

Target Information

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: brefeldin A-ribosylated substrate; C-terminal-binding protein 1; CtBP1; MGC104684; transcriptional repressor

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Gene Aliases: BARS; CTBP; CTBP1; CtBP1-L; CtBP1-S; CtBP3/BARS; D4S115h; D5H4S115; D5H4S115E; HADDTS

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UniProt ID: (Human) Q13363, (Mouse) O88712

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Entrez Gene ID: (Human) 1487, (Mouse) 13016

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Function(s)
transcription cofactor binding transcription corepressor binding chromatin binding transcription coactivator activity transcription corepressor activity protein binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein domain specific binding identical protein binding NAD binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding DNA-binding transcription factor binding C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding aldo-keto reductase (NADP) activity isocitrate dehydrogenase activity mevaldate reductase activity transcription factor binding gluconate dehydrogenase activity steroid dehydrogenase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity protein homodimerization activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity repressing transcription factor binding transcription cofactor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter protein phosphorylation Notch signaling pathway negative regulation of cell proliferation viral genome replication cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated synaptic vesicle endocytosis white fat cell differentiation regulation of cell cycle synaptic vesicle clustering transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter metabolic process positive regulation of histone deacetylation negative regulation of histone acetylation oxidation-reduction process negative regulation of histone H4 acetylation negative regulation of transcription from RNA polymerase II promoter by histone modification
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