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Product Details
H00001488-B01P
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
CTBP2 (AAH37900.1, 1 a.a. approximately 513 a.a) full-length human protein. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
See Label |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Sequence of this protein is as follows: MRPGLPGPTG LCAQTSSRGQ KSVLKQKESC GIWQLYHFLS RKQEPRWEPC VSGSSSGDGA VADLADELRG YPALCCTLPV HSYRSWAGIR PQIMNGPLHP RPLVALLDGR DCTVEMPILK DLATVAFCDA QSTQEIHEKV LNEAVGAMMY HTITLTREDL EKFKALRVIV RIGSGYDNVD IKAAGELGIA VCNIPSAAVE ETADSTICHI LNLYRRNTWL YQALREGTRV QSVEQIREVA SGAARIRGET LGLIGFGRTG QAVAVRAKAF GFSVIFYDPY LQDGIERSLG VQRVYTLQDL LYQSDCVSLH CNLNEHNHHL INDFTIKQMR QGAFLVNAAR GGLVDEKALA QALKEGRIRR AALDVHESEP FSFAQGPLKD APNLICTPHT AWYSEQASLE MREAAATEIR RAITGRIPES LRNCVNKEFF VTSAPWSVID QQAIHPELNG ATYRYPPGIV GVAPGGLPAA MEGIIPGGIP VTHNLPTVAH PSQAPSPNQP TKHGDNREHP NEQ
Target Information
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21. 3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-terminal-binding protein 2; CtBP2; ribeye; RP11-59C5.2
Gene Aliases: CTBP2
UniProt ID: (Human) P56545
Entrez Gene ID: (Human) 1488
Molecular Function:
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
negative regulation of cell proliferation
viral genome replication
positive regulation of chromatin binding
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
white fat cell differentiation
oxidation-reduction process
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