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Product Details
12852-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:400 | - |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
CTPS2 Fusion Protein Ag3490 (30-373 aa encoded by BC034986) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.19 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: CGLRVTAIK IDPYINIDAG TFSPYEHGEV FVLNDGGEVD LDLGNYERFL DINLYKDNNI TTGKIYQHVI NKERRGDYLG KTVQVVPHIT DAVQEWVMNQ AKVPVDGNKE EPQICVIELG GTIGDIEGMP FVEAFRQFQF KAKRENFCNI HVSLVPQLSA TGEQKTKPTQ NSVRALRGLG LSPDLIVCRS STPIEMAVKE KISMFCHVNP EQVICIHDVS STYRVPVLLE EQSIVKYFKE RLHLPIGDSA SNLLFKWRNM ADRYERLQKI CSIALVGKYT KLRDCYASVF KALEHSALAI NHKLNLMYID SIDLEKITET EDPVKFHEAW QKLCKADGIL VPGGF (30-373 aa encoded by B C034986)
Target Information
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CTP synthase 2; CTP synthase II; CTP synthetase 2; CTP synthetase homolog; CTP synthetase type 2; CTPsH; cytidine 5'-triphosphate synthase 2; cytidine 5'-triphosphate synthetase 2; cytidine triphosphate synthase II; UTP--ammonia ligase 2; UTP-ammonia ligase 2
Gene Aliases: A830031M15Rik; AI326475; CTPS2; Ctpsh
UniProt ID: (Human) Q9NRF8, (Mouse) P70303, (Rat) Q5U2N0
Entrez Gene ID: (Human) 56474, (Mouse) 55936, (Rat) 619580
Molecular Function:
ligase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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