Invitrogen

CTR9 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details

View all (8) CTR9 antibodies

Datasheet

Datasheet

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CTR9 Antibody in Immunofluorescence (IF) — Immunofluorescent staining of CTR9 in human cell line RT4 using a CTR9 Polyclonal Antibody (Product # PA5-64362) shows localization to nucleoplasm.

CTR9 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of CTR9 in human urinary bladder and pancreas tissues using CTR9 Polyclonal Antibody (Product # PA5-64362). Corresponding CTR9 RNA-seq data are presented for the same tissues.

CTR9 Antibody in Western Blot (WB) — Western blot analysis of CTR9 in Lane 1: Marker (kDa) 250, 130, 95, 72, 55, 36, 28, 17, 10; Lane 2: Human cell line RT-4; Lane 3: Human cell line U-251 MG; Lane 4: Human plasma; Lane 5: Human liver tissue.; Lane 6: Human tonsil tissue. tissue. Samples were probed using a CTR9 Polyclonal Antibody (Product # PA5-64362).

CTR9 Antibody in Relative expression — Relative expression in different tissues in IHC: Detection of differential expression levels of CTR9 demonstrates antibody specificity. Immunohistochemical analysis of CTR9 using anti-CTR9 Polyclonal Antibody (Product # PA5-64362), shows significant staining of CTR9 in human urinary bladder and shows minimal or weak staining in human pancreas tissues. The relative expression levels of CTR9 within each tissue is shown using RNA-Seq. {RE}

Product Details

Tested Applications

Dilution

Immunocytochemistry (ICC)

1-4 µg/mL

Immunofluorescence (IF)

1-4 µg/mL

Immunohistochemistry (IHC)

1:50-1:200

Western Blot (WB)

0.4 µg/mL

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CTR9

Conjugate

Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2640234

Product Specific Information

Immunogen sequence: YPDDVEAWIE LAQILEQTDI QGALSAYGTA TRILQEKVQA DVPPEILNNV GALHFRLGNL GEAKKYFLAS LDRAKAEAEH

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

CTR9, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ctr9; Ctr9, Paf1/RNA polymerase II complex component, homolog; Kiaa0155; p150TSP; RNA polymerase-associated protein CTR9 homolog; SH2 domain binding protein 1 (tetratricopeptide repeat containing); SH2 domain-binding protein 1; SH2-binding phosphoprotein of 150 kDa; Sh2bp1; Tetratricopeptide repeat-containing; TPR-containing; TPR-containing, SH2-binding phosphoprotein

Gene Aliases: CTR9; KIAA0155; p150; p150TSP; SH2BP1; TSBP

UniProt ID: (Human) Q6PD62

Entrez Gene ID: (Human) 9646

Function(s)

negative regulation of transcription from RNA polymerase II promoter endodermal cell fate commitment inner cell mass cell differentiation trophectodermal cell differentiation blastocyst growth transcription, DNA-templated JAK-STAT cascade histone monoubiquitination Wnt signaling pathway stem cell population maintenance positive regulation of transcription elongation from RNA polymerase II promoter histone H2B ubiquitination negative regulation of myeloid cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of histone H3-K4 methylation interleukin-6-mediated signaling pathway cellular response to lipopolysaccharide histone H3-K4 trimethylation negative regulation of mRNA polyadenylation regulation of genetic imprinting positive regulation of histone H3-K79 methylation positive regulation of histone H2B ubiquitination

Process(es)

RNA polymerase II core binding protein binding SH2 domain binding

CTR9 Polyclonal Antibody

Product Details

Product Specific Information

Target Information

Bioinformatics

Material safety data sheets (MSDS)

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