PA1-22487 detects CX3CR1 in Rat samples.
PA1-22487 has been successfully used in neutralizing, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation and Western Blot procedures.
PA1-22487 immunogen corresponds to Recombinant amino terminal fragment (Rat)..
Fractalkine, also termed neurotactin, is a membrane-bound CX3C chemokine. Rat CX3CR1, also named RBS11, was first cloned from rat brainstem, pituitary and/or spinal cord cDNA libraries. A G-protein-coupled seven-transmembrane domain receptor, it was recently identified to serve as fractalkine receptor. The human equivalent receptor is known as V28, which has been shown to mediate both the adhesive and migratory functions of fractalkine. Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-X3-C CKR-1; chemokine (C-X3-C) receptor 1; CMKBRL1; CMKDR1; CX3C chemokine receptor 1; Fractalkine receptor; GPR13; GPRV28; RBS11
Gene Aliases: Cx3cr1; Rbs11
UniProt ID: (Rat) P35411
Entrez Gene ID: (Rat) 171056
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor