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|Tested species reactivity||Human, Mouse, Non-human primate|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the second extracellular loop of human CXCR4|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Western Blot (WB)||1 µg/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
PA5-16529 targets CXCR4 in FACS and WB applications and shows reactivity with mouse, Non-human primate, and Human samples.
The PA5-16529 immunogen is a synthetic peptide derived from the second extracellular loop of human CXCR4.
CXCR4, also termed Fusin, LESTR, or HUMSTR is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CXCR4 is expressed predominantly on nanve T cell subset of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. It is also expressed on neutrophils, monocytes and various cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Salvianolic acid B inhibits SDF-1α-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor.
PA5-16529 was used in flow cytometry and western blot to study the mechanism by which salvianolic acid B inhibits SDF-1alpha-stimulated proliferation and migration of vascular smooth muscle cells
|Pan CH,Chen CW,Sheu MJ,Wu CH||Vascular pharmacology (56:98)||2012|
C-X-C chemokine receptor type 4; CD184 antigen; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor; chemokine receptor 4; CXC-R4; CXCR-4; D2S201E; fusin; HSY3RR; LAP3; LESTR; leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYY3R; pre-B-cell-derived chemokine receptor; SDF-1 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; WHIM
b2b220Clo; CD184; Cmkar4; CXCR4; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; PB-CKR; PBSF/SDF-1; Sdf1r; WHIM; WHIMS