CYB5R2 is an NADH-cytochrome b5 reductase which are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1).
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Protein Aliases: b5R.2; b5R2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2
Gene Aliases: B5R.2; CYB5R2; D630003K02Rik
Molecular Function: reductase