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Invitrogen
CYFIP1 Polyclonal Antibody
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FIGURE: 1 / 1
CYFIP1 Antibody (PA5-78419) in IHC (P)
CYFIP1 Polyclonal Antibody detects CYFIP1 protein at cytosol on mouse pancreas by immunohistochemical analysis. Sample: Paraffin-embedded mouse pancreas. CYFIP1 Polyclonal Antibody (Product # PA5-78419) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-78419
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human CYFIP1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.93 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted Reactivity: Human (100%), Rat (99%), Zebrafish (91%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyfip1; Cytoplasmic FMR1-interacting protein 1; cytoplasmic FMRP interacting protein 1; FLJ45151; KIAA0068; p140sra-1; selective hybridizing clone; Specifically Rac1-associated protein 1; Sra-1; unnamed protein product
Gene Aliases: CYFIP1; E030028J09Rik; KIAA0068; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; P140SRA-1; P140sra1; pl-1; SHYC; SRA-1; SRA1
UniProt ID: (Human) Q7L576, (Mouse) Q7TMB8
Entrez Gene ID: (Human) 23191, (Mouse) 20430
cell morphogenesis
regulation of translation
nervous system development
axon guidance
regulation of cell shape
positive regulation of lamellipodium assembly
Rac protein signal transduction
negative regulation of translation
lamellipodium assembly
cell differentiation
regulation of actin filament polymerization
neuron projection development
ruffle organization
axon extension
cognition
positive regulation of neurotrophin TRK receptor signaling pathway
dendrite extension
regulation of translation at postsynapse, modulating synaptic transmission
regulation of modification of postsynaptic actin cytoskeleton
positive regulation of Arp2/3 complex-mediated actin nucleation
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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