Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@52694dad
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:.secure
syndicationDisplayType:
      View (4) other CYLD antibodies

      Invitrogen

      CYLD Polyclonal Antibody

      References Icon 1 References
      DataSheets Icon

      Data Sheets
      Create Citation Icon

      Create Citation
      Tech Support Icon

      Tech Support

       Tech Support Icon

      Tech Support

      Catalog #:PA1-41097

      Label Icon Check your price
       

      Quantity:

      BulkOrderIcon Bulk order
      Add To Cart
      Create your first list
      What is a shared list?

      Guarantee Icon Performance Guarantee

      Product Details

      TESTED APPLICATIONS DILUTION
      Immunocytochemistry (ICC) 5-10 µg/ml
      Immunofluorescence (IF) 5-10 µg/ml
      Western Blot (WB) 2-4 µg/ml
      PUBLISHED APPLICATIONS
      Miscellaneous PubMed (MISC) See 1 publications below
      Tested Species reactivity Human
      Published species reactivity Human
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic peptide corresponding to residues D(32) K Q T Q K L L K V P K G S(45) of human CYLD.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1.0 mg/ml
      Purification Protein G
      Storage buffer PBS
      Contains 0.05% sodium azide
      Storage conditions Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
      RRID AB_2261341

      Product Specific Information

      This antibody is predicted to react with rat based on sequence homology.

      Suggested positive control: Hela whole cell extract.

      Background/Target Information

      CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (1)

      References Icon

      Have you cited this antibody in a publication? so we can reference it in this datasheet.

      Bioinformatics

      Protein Aliases: CDMT; CYLD1; CYLDI; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; EAC; FLJ20180; FLJ31664; FLJ78684; HSPC057; KIAA0849; MFT; MFT1; probable ubiquitin carboxyl-terminal hydrolase CYLD; SBS; TEM; Ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD; USPL2

      Gene Aliases: BRSS; CDMT; CYLD; CYLD1; CYLDI; EAC; HSPC057; KIAA0849; MFT; MFT1; SBS; TEM; USPL2

      UniProt ID: (Human) Q9NQC7

      Entrez Gene ID: (Human) 1540

      Molecular Function: RNA binding protein nucleic acid binding ribosomal protein

      Suggested Secondary Antibodies

      Documents

      Material safety data sheets (MSDS)

      Performance Guarantee

      If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*

      We’re here to help

      Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

      Display Info:
      cookie.CK_ISO_CODE.value:us
      cookie.CK_LANG_CODE.value:en
      cookie.CK_DISPLAY_TYPE.value:
      pageContext.request.scheme:http(not used)
      syndicationProtocol:https
      syndicationExtensionPrefix:.secure
      syndicationDisplayType: