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Invitrogen
CYP1A2 Polyclonal Antibody
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Product Details
PA1-341
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified, His-tagged, full length human P450 1A2 fusion protein.
Conjugate
Form
Liquid
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-341 detects cytochrome P450 (P450) 1A2 from human cells as well as recombinant human P450 1A2. This antibody detects, to a lesser extent, other P450 isoforms.
PA1-341 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~56 kDa protein representing recombinant human P450 1A2.
The PA1-341 immunogen is purified, His-tagged, full length human P450 1A2 fusion protein.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aryl hydrocarbon hydroxylase; Cholesterol 25-hydroxylase; CYP; CYPIA2; Cytochrome P(3)450; cytochrome P-450 peptide; Cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; Cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P(3)450; P450; P450 4; P450 form 4; P450-P3; unnamed protein product; xenobiotic monooxygenase
Gene Aliases: CP12; CYP1A2; CYPIA2; P3-450; P450(PA)
UniProt ID: (Human) P05177
Entrez Gene ID: (Human) 1544
monooxygenase activity
iron ion binding
protein binding
steroid hydroxylase activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
lyase activity
enzyme binding
heme binding
demethylase activity
caffeine oxidase activity
metal ion binding
estrogen 16-alpha-hydroxylase activity
estrogen 2-hydroxylase activity
hydroperoxy icosatetraenoate dehydratase activity
lipid metabolic process
fatty acid metabolic process
steroid catabolic process
porphyrin-containing compound metabolic process
xenobiotic metabolic process
steroid metabolic process
cholesterol metabolic process
estrogen metabolic process
toxin biosynthetic process
toxin metabolic process
post-embryonic development
alkaloid metabolic process
regulation of gene expression
monoterpenoid metabolic process
dibenzo-p-dioxin metabolic process
arachidonic acid metabolic process
epoxygenase P450 pathway
lung development
methylation
monocarboxylic acid metabolic process
xenobiotic catabolic process
hormone metabolic process
retinol metabolic process
long-chain fatty acid biosynthetic process
cellular respiration
aflatoxin metabolic process
hydrogen peroxide biosynthetic process
oxidative demethylation
cellular response to cadmium ion
omega-hydroxylase P450 pathway
olefinic compound metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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