This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-27946 targets CYP27A1 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-27946 immunogen is recombinant fragment corresponding to a region within amino acids 154 and 460 of Human CYP27A1.
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.
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Protein Aliases: 12-alpha-triol 26-hydroxylase; 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; 7-alpha; cholestanetriol 26-monooxygenase; cholesterol 27 hydroxylase; CP27; CTX; CYP27; cyt; Cytochrome P-450C27/25; Cytochrome P450 27; cytochrome P450, 27; cytochrome P450, 27a1; cytochrome P450, family 27, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1; Sterol 26-hydroxylase, mitochondrial; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase
Gene Aliases: 1300013A03Rik; CP27; CTX; CYP27; CYP27A1; P450C27