This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: RQRSLEEIPR LGQLRFFFQL FVQGYALQLH QLQVLYKAKY GPMWMSYLGP QMHVNLASAP LLEQVMRQEG KYPVRNDMEL WKEHRDQHDL TYGPFTTEGH HWYQLRQALN QRLLKPAEAA LYTDAFNEVI DDFMTRLD
Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 69%.
CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways.  It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3beta-hydroxy-5-cholestenoic acid. It is also involved in the metabolism of vitamin D3. While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized. In macrophages, 27-hydroxycholesterol generated by this enzyme may be helpful against the production of inflammatory factors associated with cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; cholestanetriol 26-monooxygenase; cyt; Cytochrome P-450C27/25; Cytochrome P450 27; cytochrome P450, family 27, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1; Sterol 26-hydroxylase, mitochondrial; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase
Gene Aliases: CP27; CTX; CYP27; CYP27A1
UniProt ID: (Human) Q02318
Entrez Gene ID: (Human) 1593