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|Tested species reactivity||Human, Rabbit|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 200-250 of human Cyp46.|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody does not react with mouse samples.
Suggested positive control: antigen standard for CYP46A1 (transient overexpression lysate).
The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum proein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CH24H; Cholesterol 24-hydroxylase; Cyp46; Cytochrome P450 46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
CP46; CYP46; CYP46A1