Peptide sequence: TYLLGSDAAA LLFNSKNEDL NAEDVYSRLT TPVFGKGVAY DVPNPVFLEQ
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CP51; CYPL1; CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; CytoChrome P450; Cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, 51; cytochrome P450, 51 (lanosterol 14-alpha-demethylase); cytochrome P450, family 51, subfamily A, polypeptide 1; cytochrome P450, subfamily 51; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; family 51; Lanosterol 14-alpha demethylase; lanosterol 14-alpha-demethylase; LDM; P450-14DM; P45014DM; P450L1; P450LI; polypeptide 1; Sterol 14-alpha demethylase; subfamily A
Gene Aliases: AI426508; BOS_3989; CP51; CYP51; CYP51A1; CYPL1; CYPLI; LDM; P450-14DM; P450L1; P450LI; RATCP14DM