Proteintech

CYTSA Polyclonal Antibody

CYTSA Antibody in Immunocytochemistry (ICC/IF)

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CYTSA Antibody (25390-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 25390-1-AP (CYTSA antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CYTSA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CYTSA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

25390-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CYTSA Fusion Protein Ag21896 (1-352 aa encoded by BC136471)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKKASRSVG SVPKVSAISK TQTAEKIKPE NSSSASTGGK LVKPGTAASL SKTKSSDDLL AGMAGGVTVT NGVKGKKSTC PSAAPSASAP AMTTVENKSK ISTGTASSTK RSTSTGNKES SSTRERLRER TRLNQSKKLP SAGQGANDMA LAKRSRSRTA TECDVRMSKS KSDNQISDRA ALEAKVKDLL TLAKTKDVEI LHLRNELRDM RAQLGINEDH SEGDEKSEKE TIMAHQPTDV ESTLLQLQEQ NTAIREELNQ LKNENRMLKD RLNALGFSLE QRLDNSEKLF GYQSLSPEIT PGNQSDGGGT LTSSVEGSAP GSVEDLLSQD ENTLMDHQHS NSMDNLDSEC SEV (1-352 aa encoded by BC136471)

Target Information

This gene encodes a protein that is leucine-rich and is thought to play a role in regulating the interaction of the cytoskeleton with a variety of cellular processes. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. Transcripts ranging in size from 4. 8 to 7. 0 kb which result from alternative polyadenylation have been reported for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin.

The Journal of biological chemistry

Mehta V,Decan N,Ooi S,Gaudreau-Lapierre A,Copeland JW,Trinkle-Mulcahy L

Wed Feb 01 00:00:00 UTC 2023

SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin.

The Journal of biological chemistry

Mehta V,Decan N,Ooi S,Gaudreau-Lapierre A,Copeland JW,Trinkle-Mulcahy L

Wed Feb 01 00:00:00 UTC 2023

SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin.

The Journal of biological chemistry

Mehta V,Decan N,Ooi S,Gaudreau-Lapierre A,Copeland JW,Trinkle-Mulcahy L

Wed Feb 01 00:00:00 UTC 2023

EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules.

Current biology : CB

Hotta T,McAlear TS,Yue Y,Higaki T,Haynes SE,Nesvizhskii AI,Sept D,Verhey KJ,Bechstedt S,Ohi R

Mon Sep 26 00:00:00 UTC 2022

In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events.

Human molecular genetics

Goering JP,Wenger LW,Stetsiv M,Moedritzer M,Hall EG,Isai DG,Jack BM,Umar Z,Rickabaugh MK,Czirok A,Saadi I

Fri Dec 17 00:00:00 UTC 2021

In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events.

Human molecular genetics

Goering JP,Wenger LW,Stetsiv M,Moedritzer M,Hall EG,Isai DG,Jack BM,Umar Z,Rickabaugh MK,Czirok A,Saadi I

Fri Dec 17 00:00:00 UTC 2021

SPECC1L regulates palate development downstream of IRF6.

Human molecular genetics

Hall EG,Wenger LW,Wilson NR,Undurty-Akella SS,Standley J,Augustine-Akpan EA,Kousa YA,Acevedo DS,Goering JP,Pitstick L,Natsume N,Paroya SM,Busch TD,Ito M,Mori A,Imura H,Schultz-Rogers LE,Klee EW,Babovic-Vuksanovic D,Kroc SA,Adeyemo WL,Eshete MA,Bjork BC,Suzuki S,Murray JC,Schutte BC,Butali A,Saadi I

Fri Mar 27 00:00:00 UTC 2020

SPECC1L regulates palate development downstream of IRF6.

Human molecular genetics

Fri Mar 27 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: cytokinesis and spindle organization A; cytospin A; Cytospin-A; Renal carcinoma antigen NY-REN-22; SPECC1-like; SPECC1-like protein; Sperm antigen with calponin homology and coiled-coil domains 1-like

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Gene Aliases: 4930470P14Rik; 4932439K10Rik; 9530057A13Rik; AI317249; CYTSA; GBBB2; KIAA0376; mKIAA0376; OBLFC1; SPECC1L

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UniProt ID: (Human) B7Z758, (Mouse) Q2KN98

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Entrez Gene ID: (Human) 23384, (Mouse) 74392

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Function(s)

molecular_function

Process(es)

negative regulation of microtubule depolymerization cell cycle cell adhesion cell migration actin cytoskeleton organization negative regulation of actin filament depolymerization cell division face morphogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CYTSA Polyclonal Antibody

CYTSA Antibody (25390-1-AP) in ICC/IF

Product Details

25390-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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