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Product Details
PA5-28789
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 1 and 45 of Human CaMKII gamma
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546265
Product Specific Information
Recommended positive controls: HepG2, mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca2+/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II gamma; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CAM2; CaMK II; caMK-II subunit gamma; CAMK2; CAMK2B; CAMK2D; CAMKB; CAMKD
Gene Aliases: CAMK; CAMK-II; CAMK2G; CAMKG
UniProt ID: (Human) Q13555, (Mouse) Q923T9
Entrez Gene ID: (Human) 818, (Mouse) 12325
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
calcium-dependent protein serine/threonine phosphatase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
calmodulin binding
ATP binding
protein homodimerization activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
MAPK cascade
protein dephosphorylation
calcium ion transport
nervous system development
regulation of skeletal muscle adaptation
insulin secretion
cell differentiation
positive regulation of GTPase activity
protein autophosphorylation
protein oligomerization
regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of cellular response to heat
regulation of relaxation of cardiac muscle
response to hypoxia
protein phosphorylation
response to oxidative stress
multicellular organism development
phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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